A tough bioadhesive based on co-assembly of polypeptide and polysaccharide for adhesion of soft tissues

• Published in: Colloids and surfaces. A, Physicochemical and engineering aspects Physicochemical and engineering aspects, 2024-05, Vol.689, p.133719, Article 133719
• Main Authors: Ren, Peng, Yang, Chaojuan, Xing, Ruirui, Yan, Xuehai
• Format: Article
• Language: English
• Subjects: adhesion; Bioadhesive; bioadhesives; Co-assembly; cohesion; complement; Hyaluronic acid; infrared spectroscopy; Poly-L-lysine; polypeptides; solutes; Tissue adhesion; viscosity
• ISSN: 0927-7757; 1873-4359
• DOI: 10.1016/j.colsurfa.2024.133719

Bioadhesive is a substitute or complement to traditional surgical sutures for promoting wound closure. In this study, we developed a simply formulated tough bioadhesive based on the co-assembly of ε-poly-L-lysine (ε-PLL) and hyaluronan (HA) using a vacuum drying strategy. The formula of the bioadhesive was optimized by adjusting the solute content and the ε-PLL/HA mass ratio. The intermolecular interactions were characterized using infrared spectroscopy. Rheological behaviors, including apparent viscosity (cohesion) and fluid types of the adhesives, were investigated. The ε-PLL/HA bioadhesive demonstrated strong adhesion to wet tissues and other abiotic substrates. [Display omitted] •A simply formulated tough bioadhesive is created through the co-assembly of ε-PLL and HA.•The bioadhesive can effectively maintain viscosity and demonstrate shear-thinning properties.•The bioadhesive exhibits a strong capability to bond wet tissues with robust adhesion strength.