Ensuring long-term stability and size control of nanoemulsion via post-microfluidization dilution toward energy saving scale-up process

• Published in: Colloids and surfaces. A, Physicochemical and engineering aspects Physicochemical and engineering aspects, 2024-06, Vol.691, p.133845, Article 133845
• Main Authors: Yun, Seunghan, Kim, Geon Woong, Jang, Jihui, Lee, Jun Bae, Kim, So Youn
• Format: Article
• Language: English
• Subjects: Dilution; Glycerol; Microfluidization; Nanoemulsion; Stability
• ISSN: 0927-7757; 1873-4359
• DOI: 10.1016/j.colsurfa.2024.133845

The production of nanoemulsions in industry is entering a new phase to meet crucial requirements. Thus, it is essential to ensure the size adjustability, long-term stability, and environmentally friendly production of nanoemulsions. In this study, we investigate these requisites for oil-in-water nanoemulsions formulated through microfluidization (MF) using polyglycerol-based nonionic surfactants with varying glycerol concentrations. Light scattering and electron microscopy results reveal that glycerol addition, an important formulation component during the MF process, facilitates the production of uniform small-sized nanoemulsions but compromises stability. To enhance stability and scalability, this study introduces the "post-MF dilution" process combining MF with a subsequent dilution process and investigates the nanoemulsion stability over 1.5 years. Results demonstrate that the proposed post-MF dilution method effectively produces nanoemulsions with enhanced stability and controlled size. Its simplicity can position it as a viable strategy for industries aiming for energy-saving and cost-effective nanoemulsion production meeting the Environmental, Social, and Governance (ESG) criteria. [Display omitted] •Size Control: Achieve precise control of nanoemulsion droplet size through glycerol concentration adjustments.•Stability Enhancement: Introduce "post-MF dilution" method for enhanced stability over 1.5 years.•Scalability Solution: Address industry challenges with a scalable strategy for energy-saving and cost-effective production.•ESG Compliance: Align with Environmental, Social, and Governance (ESG) criteria, positioning the method as eco-friendly.•Production Innovation: A novel strategy combining microfluidization and dilution for controlled and stable nanoemulsions.