Triggered protein release from calcium alginate/chitosan gastro-resistant capsules

This work aimed to develop gastro-resistant capsules, based on alginate (Alg), as an oral delivery system for enhanced bioavailability of proteins. Bovine Serum Albumin (BSA), selected as a model protein, has been encapsulated inside calcium alginate capsules, which have been coated with a thin laye...

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Bibliographic Details
Published in:Colloids and surfaces. A, Physicochemical and engineering aspects Physicochemical and engineering aspects, 2024-07, Vol.693, p.133998, Article 133998
Main Authors: Zhao, Baojuan, Alonso, Noelia Freiría, Miras, Jonathan, Vílchez, Susana, García-Celma, María José, Morral, Genoveva, Esquena, Jordi
Format: Article
Language:English
Subjects:
Coacervates
Encapsulation
Gastro-resistant capsules
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Summary:This work aimed to develop gastro-resistant capsules, based on alginate (Alg), as an oral delivery system for enhanced bioavailability of proteins. Bovine Serum Albumin (BSA), selected as a model protein, has been encapsulated inside calcium alginate capsules, which have been coated with a thin layer of chitosan (CHT) to improve its robustness and delivery profile. BSA and sodium alginate aqueous mixtures were characterized by optical microscopy and dynamic light scattering, suggesting that BSA and sodium alginate form water-in-water coacervate droplets by ionic complexation. Encapsulation of BSA-Alg colloidal dispersions was performed by introducing the BSA-Alg mixtures in CaCl2 solutions. Thus, calcium alginate capsules were formed, which were subsequently coated with CHT. Encapsulation of BSA achieved ≈99 % efficiency, the water content of capsules was ≈95 wt % and the amount of chitosan coating in wet capsules was
ISSN:0927-7757
1873-4359
DOI:10.1016/j.colsurfa.2024.133998