Responsive coatings from naturally occurring pectin polysaccharides

[Display omitted] •Thin coatings of highly esterified pectin cross-linked with calcium in ethanol.•Pectin films display thermally-responsive swelling behavior in water.•Thermal-response driven by dehydration of esterified groups.•Pectin films can be used to control cell adhesion. Pectin polysacchari...

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Bibliographic Details
Published in:Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2019-04, Vol.176, p.387-393
Main Authors: Veisi, Zeinab, Gallant, Nathan D., Alcantar, Norma A., Toomey, Ryan G.
Format: Article
Language:English
Subjects:
Animals
Coated Materials, Biocompatible - chemistry
Cross-Linking Reagents - chemistry
Fibroblasts - cytology
High-methoxyl pectin
Mice
NIH 3T3 Cells
Pectins - chemistry
Polysaccharides - chemistry
Spectroscopy, Fourier Transform Infrared
Thermal-responsive coatings
Tunable response
Ultra-thin films
Volume-phase transition
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Summary:[Display omitted] •Thin coatings of highly esterified pectin cross-linked with calcium in ethanol.•Pectin films display thermally-responsive swelling behavior in water.•Thermal-response driven by dehydration of esterified groups.•Pectin films can be used to control cell adhesion. Pectin polysaccharides have significant potential as all-natural, non-toxic “green” coatings that exhibit thermally-cued swelling behavior. Herein, ultra-thin coatings of highly-esterified pectin polysaccharides were cross-linked with calcium chloride (CaCl2) and their swelling in water was investigated with ellipsometry. At low temperatures, the coatings swell to 2–3 times their dry layer thickness. As the temperature is increased, the coatings show a pronounced decrease in swollen thickness, reminiscent of the hydrophilic-hydrophobic transition observed in lower critical solution temperature (LCST) polymers. Attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy establishes that this transition is driven by dehydration of the esterified galacturonic acid residues along the pectin backbone. By adjusting both the CaCl2 concentration used to crosslink the pectin coatings as well as pH of swelling medium, the pectin coatings could be judiciously tuned for a desired swelling response as a function of temperature. Due to their non-toxic and responsive nature, it was further demonstrated that such coatings could be used in applications to control cell adhesion.
ISSN:0927-7765
1873-4367
DOI:10.1016/j.colsurfb.2018.12.060