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Antineoplastic behavior of polydopamine nanoparticles prepared in different water/alcohol media
[Display omitted] •Polydopamine nanoparticles (PD NPs) can be synthetized in different water/NH4OH/alcohol media.•The type of alcohol and the NH4OH concentration employed in PD NP synthesis determine their size.•Fe3+-adsorption capacity of PD NPs varies depending on the alcohol used in their polymer...
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Published in: | Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2021-03, Vol.199, p.111506, Article 111506 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | [Display omitted]
•Polydopamine nanoparticles (PD NPs) can be synthetized in different water/NH4OH/alcohol media.•The type of alcohol and the NH4OH concentration employed in PD NP synthesis determine their size.•Fe3+-adsorption capacity of PD NPs varies depending on the alcohol used in their polymerization.•There is a correlation between PD NPs capacity to load Fe3+ and their toxicity for breast cancer cells.•None of the different PD NPs obtained reduce significantly the viability of normal cells.
Polydopamine nanoparticles (PD NPs) have been synthesized in the present work through the oxidative polymerization of dopamine in aqueous media containing five different types of alcohol in a constant solvent volume ratio. We have shown that the type of alcohol, along with the ammonium hydroxide concentration used in the synthesis process, conditions particle size. Additionally, it has been found that the type of alcohol employed influences the well-known capacity of polydopamine nanoparticles to adsorb iron. As a consequence, since a ferroptosis-like mechanism may account for the cytotoxicity of these nanoparticles, the type of alcohol could also have a determining role in their antineoplastic activity. Here, the existence of a correlation between the ability of polydopamine nanoparticles to load Fe3+ and their toxic effect on breast cancer cells has been proven. For instance, nanoparticles synthesized using 2-propanol adsorbed more Fe3+ and had the greatest capacity to reduce breast tumor cell viability. Moreover, none of the nanoparticle synthesized with the different alcohols significantly decreased normal cell survival. Cancer cells present greater iron-dependence than healthy cells and this fact may explain why polydopamine nanoparticles toxicity, in which Fenton chemistry could be implicated, seems tumor-specific. |
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ISSN: | 0927-7765 1873-4367 |
DOI: | 10.1016/j.colsurfb.2020.111506 |