Photo-responsive platelet vesicles-iron oxide nanoparticles-bioglass composite for orthopedic bioengineering

In our study, we present an innovative approach to precisely modulate cellular activity and facilitate bone regeneration through non-invasive, remote stimuli application. Our methodology involves the creation of a composite material, namely platelet vesicles, iron oxide nanoparticles, and 45 s5 Biog...

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Bibliographic Details
Published in:Composite structures 2024-09, Vol.344, p.118263, Article 118263
Main Authors: Chuang, Andrew E.-Y., Weng, Pei-Wei, Liu, Chia-Hung, Jheng, Pei-Ru, Rethi, Lekshmi, Trung Nguyen, Hieu, Lu, Hsien-Tsung
Format: Article
Language:English
Subjects:
Bioglass
Hydrogel F127
Near-Infrared Light Stimulation
Photoelectric and Photothermal (PET/PTT) Environment
PLTV-IO NPs/BG Composite
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Summary:In our study, we present an innovative approach to precisely modulate cellular activity and facilitate bone regeneration through non-invasive, remote stimuli application. Our methodology involves the creation of a composite material, namely platelet vesicles, iron oxide nanoparticles, and 45 s5 Bioglass (PLTV-IO NPs/BG), designed to establish a photoelectric and photothermal (PET/PTT) environment around an implant. Under near-infrared (NIR) light, the PLTV-IO NPs/BG composite demonstrates mild-hyperthermic and photoelectric responsive effects. Notably, this application enhances the mechanical strength of the hydrogel F127 and encourages sequential cell management. These observed effects collectively indicate the material’s potential in tissue engineering, specifically for bone regeneration. Our research introduces a biological therapeutic strategy that achieves remote and non-invasive regulation of cellular progression behaviors within phototherapeutic microenvironments, effectively harnessing the power of NIR light. This multidimensional approach holds promise for advancing the field of biomedical research and therapeutic applications.
ISSN:0263-8223
1879-1085
DOI:10.1016/j.compstruct.2024.118263