Recent advances using gold nanoparticles as a promising multimodal tool for tissue engineering and regenerative medicine

[Display omitted] •Gold nanoparticles as a multimodal nanotool.•Gold nanoparticles promote stem cells differentiation for bone tissue engineering.•Gold nanoparticles enhance the mechanical and adhesive properties of scaffolds.•Gold nanoparticles favor the nanostructure of scaffolds to guide cell beh...

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Bibliographic Details
Published in:Current opinion in solid state & materials science 2017-04, Vol.21 (2), p.92-112
Main Authors: Vial, Stephanie, Reis, Rui L., Oliveira, J. Miguel
Format: Article
Language:English
Subjects:
Gold nanoparticle
Regenerative medicine
Scaffold
Stem cells
Tissue engineering
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Summary:[Display omitted] •Gold nanoparticles as a multimodal nanotool.•Gold nanoparticles promote stem cells differentiation for bone tissue engineering.•Gold nanoparticles enhance the mechanical and adhesive properties of scaffolds.•Gold nanoparticles favor the nanostructure of scaffolds to guide cell behavior. Gold nanoparticles (AuNPs) have arisen a lot of interest in the clinical realms of nanomedicine. Despite the large advances made in cancer research using AuNPs, their use in tissue engineering and regenerative medicine (TERM) is still in its infancy. Herein, it is discussed the properties, functionalization, and emerging use of AuNPs as a multifunctional and multimodal platform for drug delivery, phototherapy, diagnostic and cell imaging purposes. Moreover, the recent reports related to the ability of AuNPs to enhance stem cell differentiation for bone tissue engineering, to enhance the mechanical and adhesive properties of scaffolds and surface topography to guide cell behaviors are addressed.
ISSN:1359-0286
DOI:10.1016/j.cossms.2016.03.006