Using terahertz pulsed spectroscopy to study crystallinity of pharmaceutical materials

The application of terahertz pulsed spectroscopy to polymorphic, liquid crystalline and amorphous forms of pharmaceutical compounds has been investigated. The different polymorphic forms of carbamazepine and enalapril maleate exhibit distinct terahertz absorbance spectra. In contrast to crystalline...

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Bibliographic Details
Published in:Chemical physics letters 2004-05, Vol.390 (1), p.20-24
Main Authors: Strachan, Clare J., Rades, Thomas, Newnham, David A., Gordon, Keith C., Pepper, Michael, Taday, Philip F.
Format: Article
Language:English
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Summary:The application of terahertz pulsed spectroscopy to polymorphic, liquid crystalline and amorphous forms of pharmaceutical compounds has been investigated. The different polymorphic forms of carbamazepine and enalapril maleate exhibit distinct terahertz absorbance spectra. In contrast to crystalline indomethacin and fenoprofen calcium, amorphous indomethacin and liquid crystalline fenoprofen calcium show no absorption modes, which is likely to be due to a lack of order. These findings suggest that the modes observed are due to crystalline phonon and possibly hydrogen-bonding vibrations. The large spectral differences between different forms of the compounds studied is evidence that terahertz pulsed spectroscopy is well-suited to distinguishing crystallinity differences in pharmaceutical compounds.
ISSN:0009-2614
1873-4448
DOI:10.1016/j.cplett.2004.03.117