Low-power homonuclear dipolar recoupling in solid-state NMR developed using optimal control theory

Novel low-power pulse sequences for homonuclear dipolar recoupling in biological solid-state NMR spectroscopy are presented. The pulse sequences are developed numerically using the S impson simulation program in combination with optimal control procedures. The quality criteria for the experiment opt...

Full description

Saved in:
Bibliographic Details
Published in:Chemical physics letters 2005-10, Vol.414 (1), p.204-209
Main Authors: Kehlet, Cindie, Vosegaard, Thomas, Khaneja, Navin, Glaser, Steffen J., Nielsen, Niels Chr
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Novel low-power pulse sequences for homonuclear dipolar recoupling in biological solid-state NMR spectroscopy are presented. The pulse sequences are developed numerically using the S impson simulation program in combination with optimal control procedures. The quality criteria for the experiment optimizations are the achievement of the highest possible sensitivity for powder samples under typical experimental inhomogeneous radio-frequency (rf) field conditions, while keeping the rf field strength sufficiently low to prevent undesirable sample heating in biological applications. The new dipolar recoupling methods are demonstrated numerically and experimentally by double-quantum filtration magic-angle spinning NMR experiments for which sensitivity gains approaching a factor of 2 is observed.
ISSN:0009-2614
1873-4448
DOI:10.1016/j.cplett.2005.08.061