Antiphospholipid antibody syndrome

Antiphospholipid antibody syndrome (APS) is characterized by recurrent pregnancy losses and/or thrombotic events (both arterial and venous) with persistently positive lupus anticoagulant or antiphospholipid antibodies. Activation of complements, platelets and endothelial cells by the anticardiolipin...

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Bibliographic Details
Published in:Clinical queries, nephrology (India) nephrology (India), 2014-01, Vol.3 (1), p.9-14
Main Authors: Parida, Jyoti R., Misra, Durga Prasanna, Wakhlu, Anupam, Agarwal, Vikas
Format: Article
Language:English
Subjects:
Anti β2Glycoprotein-1
Anticardiolipin antibodies
Lupus anticoagulant
Pregnancy loss
Thrombosis
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Summary:Antiphospholipid antibody syndrome (APS) is characterized by recurrent pregnancy losses and/or thrombotic events (both arterial and venous) with persistently positive lupus anticoagulant or antiphospholipid antibodies. Activation of complements, platelets and endothelial cells by the anticardiolipin-β2GP-1 complex plays a major role in pathogenesis of thrombosis. Treatment is with anticoagulation (warfarin/heparin), with steroids needed in the presence of catastrophic APS or cytopenias. Upto a third of patients may have significant long term morbidity.
ISSN:2211-9477
2211-9477
DOI:10.1016/j.cqn.2014.03.007