Recent developments in l -asparaginase discovery and its potential as anticancer agent

Highlights • l -Asparaginase kills asparagine dependent leukaemia cells by hydrolysing asparagine. • Bacterial l -asparaginase is used for treatment of leukaemia and other blood cancer. • Bacterial l -asparaginase is associated with several adverse reactions. • These adverse reactions necessitate de...

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Bibliographic Details
Published in:Critical reviews in oncology/hematology 2016-04, Vol.100, p.1-10
Main Authors: Shrivastava, Abhinav, Khan, Abdul Arif, Khurshid, Mohsin, Kalam, Mohd Abul, Jain, Sudhir K, Singhal, Pradeep K
Format: Article
Language:English
Subjects:
Acute lymphoblastic leukaemia
Anticancer
Antineoplastic Agents - pharmacology
Asparaginase - pharmacology
Erwinase
Hematology, Oncology and Palliative Medicine
Humans
Kidrolase
l-Asparaginase
l-Asparagine
PEG-asparaginase
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
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Summary:Highlights • l -Asparaginase kills asparagine dependent leukaemia cells by hydrolysing asparagine. • Bacterial l -asparaginase is used for treatment of leukaemia and other blood cancer. • Bacterial l -asparaginase is associated with several adverse reactions. • These adverse reactions necessitate development of l -asparaginase from other sources.
ISSN:1040-8428
1879-0461
DOI:10.1016/j.critrevonc.2015.01.002