Toll-like receptor 4 signaling: A common biological mechanism of regimen-related toxicities

Highlights • Regimen-related toxicities exhibit symptom clusters indicative of common biology. • Neuropathy and GI toxicity are dose-limiting side effects of chemotherapy. • TLR4 has established roles in neuropathic pain through glial activation. • TLR4 is an emerging mediator of GI toxicity. • Targ...

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Bibliographic Details
Published in:Cancer treatment reviews 2015-02, Vol.41 (2), p.122-128
Main Authors: Wardill, Hannah R, Van Sebille, Ysabella Z.A, Mander, Kimberley A, Gibson, Rachel J, Logan, Richard M, Bowen, Joanne M, Sonis, Stephen T
Format: Article
Language:English
Subjects:
Chemotherapy
Glial activation
Gut toxicity
Hematology, Oncology and Palliative Medicine
Neuropathy
Neurotoxicity
Toll-like receptor 4
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Summary:Highlights • Regimen-related toxicities exhibit symptom clusters indicative of common biology. • Neuropathy and GI toxicity are dose-limiting side effects of chemotherapy. • TLR4 has established roles in neuropathic pain through glial activation. • TLR4 is an emerging mediator of GI toxicity. • Targeting TLR4 provides an opportunity to simultaneously treat both toxicities.
ISSN:0305-7372
1532-1967
DOI:10.1016/j.ctrv.2014.11.005