HES1 in immunity and cancer

Highlights • HES1 is regulated by the NOTCH signalling pathway as well as the wnt and hedgehog pathways. • HES1 plays an important role in T cell development and cancer. • HES1 represents a potent therapeutic target in cancer and leukaemia.

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Bibliographic Details
Published in:Cytokine & growth factor reviews 2016-08, Vol.30, p.113-117
Main Authors: Rani, Aradhana, Greenlaw, Roseanna, Smith, Richard A, Galustian, Christine
Format: Article
Language:English
Subjects:
Advanced Basic Science
Cancer
Cytokine
HES1
Immunity
NOTCH
Therapy
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Description
Summary:Highlights • HES1 is regulated by the NOTCH signalling pathway as well as the wnt and hedgehog pathways. • HES1 plays an important role in T cell development and cancer. • HES1 represents a potent therapeutic target in cancer and leukaemia.
ISSN:1359-6101
DOI:10.1016/j.cytogfr.2016.03.010