Crosstalk between lncRNAs in the apoptotic pathway and therapeutic targets in cancer

The assertion that a significant portion of the mammalian genome has not been translated and that non-coding RNA accounts for over half of polyadenylate RNA have received much attention. In recent years, increasing evidence proposes non-coding RNAs (ncRNAs) as new regulators of various cellular proc...

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Published in:Cytokine & growth factor reviews 2022-06, Vol.65, p.61-74
Main Authors: Ebrahimi, Nasim, Parkhideh, Sahar, Samizade, Setare, Esfahani, Alireza Nasr, Samsami, Sahar, Yazdani, Elnaz, Adelian, Samaneh, Chaleshtori, Siavash Rahimian, Shah-Amiri, Kamal, Ahmadi, Amirhossein, Aref, Amir Reza
Format: Article
Language:English
Subjects:
Apoptosis
Biomarkers
Cancer therapy
LncRNAs
Therapeutic target
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Summary:The assertion that a significant portion of the mammalian genome has not been translated and that non-coding RNA accounts for over half of polyadenylate RNA have received much attention. In recent years, increasing evidence proposes non-coding RNAs (ncRNAs) as new regulators of various cellular processes, including cancer progression and nerve damage. Apoptosis is a type of programmed cell death critical for homeostasis and tissue development. Cancer cells often have inhibited apoptotic pathways. It has recently been demonstrated that up/down-regulation of various lncRNAs in certain types of tumors shapes cancer cells' response to apoptotic stimuli. This review discusses the most recent studies on lncRNAs and apoptosis in healthy and cancer cells. In addition, the role of lncRNAs as novel targets for cancer therapy is reviewed here. Finally, since it has been shown that lncRNA expression is associated with specific types of cancer, the potential for using lncRNAs as biomarkers is also discussed. [Display omitted] •Apoptosis inhibition is one of drug resistance mechanism in cancer cells.•lncRNAs can regulate apoptosis pathway.•Various lncRNAs act as oncogene or tumor suppressor by apoptosis regulation.•Role of lncRNA in apoptosis regulation is crucial for drug resistance studies.•Besides to apoptosis, other cellular processes can be regulated by lncRNA.
ISSN:1359-6101
DOI:10.1016/j.cytogfr.2022.04.003