Role of circular RNA in myocardial ischemia and ageing-related diseases

Circular RNA (circRNA) is a new endogenous transcription product, which has attracted significant attention in RNA biology research.CircRNA comprise exons or introns involved in regulation of various mechanisms.These molecules are stable and species-specific, as well as cell and tissue-specific.Card...

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Bibliographic Details
Published in:Cytokine & growth factor reviews 2022-06, Vol.65, p.1-11
Main Authors: Gao, Xiaolong, Tian, Xin, Huang, Ye, Fang, Rong, Wang, Gendi, Li, Dan, Zhang, Junru, Li, Tian, Yuan, Ruihua
Format: Article
Language:English
Subjects:
Cardiac aging
CircRNA
Metabolism
Myocardial ischemia
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Summary:Circular RNA (circRNA) is a new endogenous transcription product, which has attracted significant attention in RNA biology research.CircRNA comprise exons or introns involved in regulation of various mechanisms.These molecules are stable and species-specific, as well as cell and tissue-specific.Cardiovascular diseases particularly myocardial ischemia and ageing-related diseases, pose a major health care burden and novel treatments and biomarkers should be explored.Recent findings indicate that circRNAs are implicated in biological processes, such as glucose metabolism, fatty acid oxidation, mitochondrial biosynthesis, implying that they are potential targets for myocardial ischemia treatment.In the present review, the functions of circRNAs in the heart are described, with emphasis given on in the relationship with myocardial ischemia and cardiac aging-related diseases.Directions for future research are also summarized. •Myocardial ischemia and cardiac aging are closely related to cardiovascular disease.•CircRNA is a special noncoding RNA which plays an important role in heart disease.•CircRNA has high application value and is worthy of further study.
ISSN:1359-6101
DOI:10.1016/j.cytogfr.2022.04.005