Role of the Wnt and GTPase pathways in breast cancer tumorigenesis and treatment

Breast cancer (BC) is the most frequently diagnosed cancer among women in all the populations of the world. Although the BC mortality rate has declined, resistance to treatment is still a significant challenge for patient survival. Various cellular signaling pathways, such as Wnt and Rho/GTPase have...

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Bibliographic Details
Published in:Cytokine & growth factor reviews 2022-10, Vol.67, p.11-24
Main Authors: Ebrahimi, Nasim, Kharazmi, Kamyar, Ghanaatian, Masoud, Miraghel, Seyed Ali, Amiri, Yasaman, Seyedebrahimi, Seyede Sanaz, Mobarak, Halimeh, Yazdani, Elnaz, Parkhideh, Sahar, Hamblin, Michael R., Aref, Amir Reza
Format: Article
Language:English
Subjects:
Breast cancer
Resistance to treatment
Rho/GTPase proteins
Wnt signaling pathway
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Summary:Breast cancer (BC) is the most frequently diagnosed cancer among women in all the populations of the world. Although the BC mortality rate has declined, resistance to treatment is still a significant challenge for patient survival. Various cellular signaling pathways, such as Wnt and Rho/GTPase have been linked to the development, migration, and metastasis of BC, and also in treatment resistance mechanisms. Some studies have shown an association between two important cellular pathways, Wnt and Rho/GTPase, in cytoskeleton activation and cancer invasion. However, their involvement in BC has received little attention. This review summarizes the Wnt and Rho/GTPases signaling pathway functions, and also the crosstalk between these pathways in the progression, metastasis, and drug resistance mechanisms in BC. Considering the signaling pathways involved in BC tumorigenesis, future studies will need to investigate possible molecular interventions and new opportunities for the development of personalized strategies for BC treatment in order to improve overall outcomes. [Display omitted] •GTPase and Wnt pathways are involved pathways in various cell process that any disruption in those can lead to tumorigenesis.•Mutation in members of GTPase pathways caused uncontrolled cell division and cancer.•Both of wnt and GTPase pathways are involved in drug resistance in breast cancer.•There are a strong crosstalk between Wnt and GTPase pathways.•Understanding the relationship between the two signaling pathways suggests common therapeutic targets that can be more effective.
ISSN:1359-6101
DOI:10.1016/j.cytogfr.2022.05.001