Genetically engineered mouse models for lung cancer

Lung cancer is a heterogeneous lethal disease that can be subdivided into small cell lung cancer and non-small cell lung cancer. The ability to model lung cancer in vivo in a laboratory model will facilitate the development of new therapeutic and diagnostic tools to combat this disease. The use of t...

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Bibliographic Details
Published in:Drug discovery today. Disease models 2005, Vol.2 (1), p.35-40
Main Authors: Li, Huaiguang, Kwak, Inseok, DeMayo, Francesco J.
Format: Article
Language:English
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Summary:Lung cancer is a heterogeneous lethal disease that can be subdivided into small cell lung cancer and non-small cell lung cancer. The ability to model lung cancer in vivo in a laboratory model will facilitate the development of new therapeutic and diagnostic tools to combat this disease. The use of transgenic and gene targeting approaches have allowed the development of genetically engineered mouse models for both types of lung cancer. This review will discuss the approaches to the generation of mouse models for lung cancer. Vincent Goffin – INSERM, Faculté de Médecine Necker, Paris, France Christopher J. Ormandy – Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
ISSN:1740-6757
1740-6757
DOI:10.1016/j.ddmod.2005.05.020