Lipid Phase Perturbations and the Unfolded Protein Response

Recent studies of the consequences of ganglioside accumulation in lysosomal storage disease and free cholesterol accumulation in cell membranes in atherosclerosis suggest an unexpected link between perturbation of the endoplasmic reticulum membrane's lipid phase, induction of the unfolded prote...

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Bibliographic Details
Published in:Developmental Cell 2004-09, Vol.7 (3), p.287-288
Main Authors: Ron, David, Oyadomari, Seiichi
Format: Article
Language:English
Subjects:
Animals
Arteriosclerosis - metabolism
Cell Death
Cell Membrane - metabolism
Endoplasmic Reticulum - metabolism
Humans
Lipid Metabolism
Lipids - chemistry
Protein Denaturation
Protein Folding
Proteins - chemistry
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Summary:Recent studies of the consequences of ganglioside accumulation in lysosomal storage disease and free cholesterol accumulation in cell membranes in atherosclerosis suggest an unexpected link between perturbation of the endoplasmic reticulum membrane's lipid phase, induction of the unfolded protein response, and cell death.
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2004.08.011