Pharmacokinetics, pharmacodynamics and toxicology of new psychoactive substances (NPS): 2C-B, 4-fluoroamphetamine and benzofurans

Highlights • A number of new psychoactive substances (NPS) enter the European drug market yearly. • Frequently detected NPS are 4-bromo-2,5-dimethoxyphenethylamine (2C-B), 4-fluoroamphetamine (4-FA) and benzofurans. • 2C-B, 4-FA and benzofurans can cause sympathomimetic effects. • In contrast to 4-F...

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Bibliographic Details
Published in:Drug and alcohol dependence 2015-12, Vol.157, p.18-27
Main Authors: Nugteren-van Lonkhuyzen, Johanna J, van Riel, Antoinette J.H.P, Brunt, Tibor M, Hondebrink, Laura
Format: Article
Language:English
Subjects:
Amphetamines - adverse effects
Amphetamines - pharmacokinetics
Benzofurans - adverse effects
Benzofurans - pharmacokinetics
Clinical
Designer drugs
Dimethoxyphenylethylamine - adverse effects
Dimethoxyphenylethylamine - analogs & derivatives
Dimethoxyphenylethylamine - pharmacokinetics
Humans
Legal highs
Psychiatry
Psychotropic Drugs - adverse effects
Psychotropic Drugs - pharmacokinetics
Research chemicals
Street Drugs - adverse effects
Street Drugs - pharmacokinetics
Toxicology
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Summary:Highlights • A number of new psychoactive substances (NPS) enter the European drug market yearly. • Frequently detected NPS are 4-bromo-2,5-dimethoxyphenethylamine (2C-B), 4-fluoroamphetamine (4-FA) and benzofurans. • 2C-B, 4-FA and benzofurans can cause sympathomimetic effects. • In contrast to 4-FA, 2C-B and benzofurans can cause severe psychological symptoms.
ISSN:0376-8716
1879-0046
DOI:10.1016/j.drugalcdep.2015.10.011