Metabolic syndrome and albuminuria show an additive effect in modulating glomerular filtration rate in patients with Type 2 Diabetes Mellitus

Abstract Background Although metabolic syndrome (MetSyn) or albuminuria (MA) most often occurs in concomitance in Type 2 Diabetes Mellitus patients (T2DM), their mode of interaction in increasing the risk of low glomerular filtration rate (GFR) has been poorly investigated. Objective We evaluated in...

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Bibliographic Details
Published in:Diabetes & metabolic syndrome clinical research & reviews 2009-09, Vol.3 (3), p.139-142
Main Authors: Cignarelli, Mauro, Lamacchia, Olga, Cardinale, Giada, Rauseo, Anna, Mastroianno, Sandra, Gesualdo, Loreto, De Cosmo, Salvatore
Format: Article
Language:English
Subjects:
Albuminuria
Chronic kidney disease
Diabetic nephropathy
Endocrinology & Metabolism
Metabolic syndrome
Renal failure
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Summary:Abstract Background Although metabolic syndrome (MetSyn) or albuminuria (MA) most often occurs in concomitance in Type 2 Diabetes Mellitus patients (T2DM), their mode of interaction in increasing the risk of low glomerular filtration rate (GFR) has been poorly investigated. Objective We evaluated in a cohort of 1659 T2DM patients the relationship between MetSyn and MA in modulating the risk for low GFR. The risk of developing low GFR by graded number of MetSyn traits was also evaluated. Methods This was a cross-sectional study where 1659 T2DM patients were studied. Low GFR was defined as estimated-GFR (e-GFR)
ISSN:1871-4021
1878-0334
DOI:10.1016/j.dsx.2009.04.011