Microwave-assisted solvent-free synthesis and spectral properties of some dimethine cyanine dyes as fluorescent dyes for DNA detection

A series of dimethine cyanine dyes were synthesized in a fast, efficient and high yield by the condensation of quaternary salts with 1 H-indole-3-carbaldehyde in the presence of piperidine under solvent-free microwave irradiation. The products were identified by 1H NMR, IR, UV–vis spectroscopy and e...

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Bibliographic Details
Published in:Dyes and pigments 2008-11, Vol.79 (2), p.205-209
Main Authors: Zhang, Xiang-Han, Wang, Lan-Ying, Nan, Zhi-Xiang, Tan, Shi-Huan, Zhang, Zu-Xun
Format: Article
Language:English
Subjects:
BSA
Dimethine cyanine dye
DNA
Fluorescent quantum yield
Microwave irradiation
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Summary:A series of dimethine cyanine dyes were synthesized in a fast, efficient and high yield by the condensation of quaternary salts with 1 H-indole-3-carbaldehyde in the presence of piperidine under solvent-free microwave irradiation. The products were identified by 1H NMR, IR, UV–vis spectroscopy and elemental analysis. The absorption and fluorescence properties of the dyes in both the free state and DNA or BSA were investigated. Significant enhancement of the fluorescent quantum yield was observed for all the dyes in the presence of DNA, with one compound demonstrating excellent sensitivity as a fluorescent probe.
ISSN:0143-7208
1873-3743
DOI:10.1016/j.dyepig.2008.02.010