Highly photostable, lysosome-targeted BODIPYs with green to near-infrared emission for lysosome imaging in living cells

A series of highly photostable, lysosome-targeted BODIPYs with tunable fluorescence from green to the near-infrared region was developed. The probes were found to show an accurate lysosome-targeting ability with high selectivity and high photostability under continuous excitation irradiation. The re...

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Bibliographic Details
Published in:Dyes and pigments 2018-08, Vol.155, p.30-35
Main Authors: Ye, Zhuo, Xiong, Chao, Pan, Jian, Su, Dongdong, Zeng, Lintao
Format: Article
Language:English
Subjects:
BODIPY
Fluorescence
Imaging
Lysosome-targeted
Photostable
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Summary:A series of highly photostable, lysosome-targeted BODIPYs with tunable fluorescence from green to the near-infrared region was developed. The probes were found to show an accurate lysosome-targeting ability with high selectivity and high photostability under continuous excitation irradiation. The results show that these lysosome-targeted BODIPYs offer a simple and convenient tool for fluorescence imaging of lysosomes, which will be valuable for understanding the activity and function of lysosomes in related cells. [Display omitted] •BODIPY derivatives with green to near-infrared emission are developed.•The optical properties of BODIPY derivatives are investigated.•BODIPY derivatives show highly photostable properties in vitro and in live cells.•BODIPY derivatives show an accurate lysosome-targeting ability with high selectivity.
ISSN:0143-7208
1873-3743
DOI:10.1016/j.dyepig.2018.03.015