Amphiphilic axially modified cationic indium-porphyrins linked to hydrophilic magnetic nanoparticles for photodynamic antimicrobial chemotherapy against gram-negative strain; Escherichia coli

In this study, we report on the synthesis, characterization, and application of indium porphyrins linked to silver core-shell magnetic nanoparticles for in vitro photodynamic antimicrobial chemotherapy (PACT) against gram-negative strain, E. coli. This work compares the photophysicochemical and PACT...

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Bibliographic Details
Published in:Dyes and pigments 2021-08, Vol.192, p.109262, Article 109262
Main Authors: Makola, L. Collen, Mgidlana, Sithi, Nyokong, Tebello
Format: Article
Language:English
Subjects:
Amphiphilic
Escherichia coli
Lipophilicity
Magnetic nanoparticles
Photodynamic antimicrobial chemotherapy
Photosensitizer
Porphyrins
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Summary:In this study, we report on the synthesis, characterization, and application of indium porphyrins linked to silver core-shell magnetic nanoparticles for in vitro photodynamic antimicrobial chemotherapy (PACT) against gram-negative strain, E. coli. This work compares the photophysicochemical and PACT activities of InCl 5-p-carboxyphenyl-10-15-20-(tris-4-methylpyridinium)-triiodide porphyrin (1), InCl 5-p-carboxyphenyl-10-15-20-(tris-4-hexylpyridinium)-triiodide porphyrin (2), In (para-aminophenyl) 5,10,15,20-tetrakis(4-methylpyridinium)-tetraiodide porphyrin (3), and In (para-aminophenyl) 5,10,15,20-tetrakis(4-hexylpyridinium)-tetraiodide porphyrin (4). The comparisons were based on the structure and number of charges. Hydrophilic and hydrophobic characters of the amphiphilic porphyrins were studied by comparing the effect of the different alkyl halides (iodomethane and iodohexane) quaternizing agents. The porphyrin complexes were further linked to magnetic nanoparticles to facilitate antimicrobial synergy and recovery of the complexes after use. High Log reduction values ranging from 7.19 to 9.58 were obtained for the quaternized complexes. •Quaternized indium porphyrins are linked to silver core-shell magnetic nanoparticles.•The conjugates are used for photodynamic antimicrobial chemotherapy (PACT) against E. coli.•Porphyrins quaternized with shorter alkyl halide and the conjugates show better on PACT activity.•High Log reduction values ranging from 7.19 to 9.58 were obtained for the quaternized complexes and their conjugates.
ISSN:0143-7208
1873-3743
DOI:10.1016/j.dyepig.2021.109262