Benz[e]indole-bearing aminosquaraine dyes: Which of the amines introduced into the squaric ring will be able to induce the best in vitro photodynamic effect?

The introduction of amines into the four-membered central ring of squaraine dyes has proven to be a good way to improve certain attributes of the molecules such as their aqueous solubility, their absorption at higher wavelengths, as well as inducing a more effective interaction with certain biologic...

Full description

Saved in:
Bibliographic Details
Published in:Dyes and pigments 2023-07, Vol.215, p.111239, Article 111239
Main Authors: Lima, Eurico, Barroso, Andreia G., Ferreira, Octávio, Boto, Renato E., Fernandes, José R., Almeida, Paulo, Silvestre, Samuel M., Santos, Adriana O., Reis, Lucinda V.
Format: Article
Language:English
Subjects:
Albumin interaction
Aminosquaraine dyes
Cancer
Photodynamic therapy
Photosensitizer
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The introduction of amines into the four-membered central ring of squaraine dyes has proven to be a good way to improve certain attributes of the molecules such as their aqueous solubility, their absorption at higher wavelengths, as well as inducing a more effective interaction with certain biological targets. Therefore this chemical modification has been studied regarding their application in the development of potential photosensitizers for photodynamic therapy. This work presents the synthesis of several N-ethyl chain benz[e]indole-based aminosquaraine dyes with amines of increasing complexity (amino 
ISSN:0143-7208
1873-3743
DOI:10.1016/j.dyepig.2023.111239