The effect of di-2-ethylhexyl phthalate on inflammation and lipid metabolic disorder in rats

Plasticizer di-2-ethylhexyl phthalate (DEHP) can induce lipid metabolic disorder. There was a chronic low level inflammatory response in adipose tissue of patients with lipid metabolic disorder. But the effect of inflammation on lipid metabolic disorder induced by DEHP is unclear. The present study...

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Bibliographic Details
Published in:Ecotoxicology and environmental safety 2019-04, Vol.170, p.391-398
Main Authors: Zhou, Liting, Chen, Huaiji, Xu, Qi, Han, Xu, Zhao, Yaming, Song, Xinyue, Zhao, Tianyang, Ye, Lin
Format: Article
Language:English
Subjects:
Di-2-ethylhexyl phthalate
Environmental endocrine disruptors
Inflammation
Lipid metabolism
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Summary:Plasticizer di-2-ethylhexyl phthalate (DEHP) can induce lipid metabolic disorder. There was a chronic low level inflammatory response in adipose tissue of patients with lipid metabolic disorder. But the effect of inflammation on lipid metabolic disorder induced by DEHP is unclear. The present study was undertaken to explore the effect of di-2-ethylhexyl phthalate on inflammation and lipid metabolic disorder in rats. Eighty healthy 21-day-old Wistar rats were randomly divided into 4 groups and administered DEHP by gavage at 0, 5, 50, and 500 mg/kg/ d for 8 weeks. Morphological changes of adipose tissue, the levels of IL-1β, TNF-α, LEP, and ADP in rat serum and adipose tissue, the serum TC, TG, HDL-C and LDL-C, the mRNA and protein expression levels of lipid metabolism-related gene CEBP/β and inflammation-related gene CD68 were measured. After exposure to DEHP, the weight of rats in the high dose group was significantly higher than that in the control group (p 
ISSN:0147-6513
1090-2414
DOI:10.1016/j.ecoenv.2018.12.009