Occurrence and health risk assessment of pharmaceutical and personal care products (PPCPs) in tap water of Shanghai

• Published in: Ecotoxicology and environmental safety 2019-11, Vol.183, p.109497, Article 109497
• Main Authors: Liu, Min, Yin, Haowen, Wu, Qiang
• Format: Article
• Language: English
• Subjects: Distribution characteristics; Human health risk assessment; Phenicols and chatain drugs; PPCPs; Tap water
• ISSN: 0147-6513; 1090-2414
• DOI: 10.1016/j.ecoenv.2019.109497

A monitoring study of 71 pharmaceuticals and personal care products (PPCPs) in tap water covered all districts of Shanghai. Nineteen PPCPs were detected in all samples, and most of them were detected with high concentration. Ten compounds were found with highest concentrations and their detection frequencies were over 80%, included thiamphenicol  (101.54 ng/L), florfenicol (84.56 ng/L), valsartan (66.84 ng/L), irbesartan (38.35 ng/L) hydrochlorothiazide (33.13 ng/L), 4-acetaminopyrine (48.16 ng/L), propylparaben (47.50 ng/L), dicyclohexylamine (42.33 ng/L), primidone (32.85 ng/L) and bisphenol A (31.51 ng/L). Only 6 PPCPs were not detected in all samples. Detection frequency of PPCPs was between 50% and 70% in most tap waters, but the total concentration of PPCPs ranged from 71.6 to 361 ng/L. Phenicols was the dominant type with average value of 100 ng/L, accounting for over 50% of most samples, followed by cardiovascular and psychotropic drugs with average value of 26.3 and 12.1 ng/L, respectively. In general, the residues of PPCPs in tap water of suburb were higher than those in central districts. The maximum residues happened in D district with the average concentration of 355 ng/L, followed by J, H and Cb districts with the average concentration of 269, 251 and 215 ng/L. In the same district, the content and distribution of PPCPs in tap waters were similar supplied by different water treatment plants. While those are some differences among tap waters inlet from the same water sources. Individual compound was expected to pose a negligible risk to human health with risk quotients (RQ) less than 1, except primidone which may pose potential risk to infants. •Phenicols and chatain drugs were the dominant compounds in tap water of Shanghai.•The level and characteristics of PPCPs in tap waters were similar in the same district.•The level of PPCPs in tap water in suburb was commonly higher than those in central districts, especially for D, H and J districts.•Individual compound was expected to pose negligible risk to human health, but the attention should be paid to a few compounds especially for infants.