Comparative study between novel sedative drug (dexmedetomidine) versus midazolam–propofol for conscious sedation in pediatric patients undergoing oro-dental procedures

• Published in: Egyptian journal of anaesthesia 2010-10, Vol.26 (4), p.299-304
• Main Authors: Al Taher, Waleed M.A., Mansour, Emad E., El Shafei, Mohamed N.
• Format: Article
• Language: English
• Subjects: Dexmedetomidine; Midazolam; Propofol; Sedation for pediatric dentistry
• ISSN: 1110-1849; 1687-1804; 1110-1849
• DOI: 10.1016/j.egja.2010.04.002

A comparative study to evaluate the effect of dexmedetomidine as a sedative in pediatric dental patients in comparison to the currently used combination of midazolam and propofol. Sixty ASA I children (4–10years old) referred from the outpatient clinic of the pediatric dentistry department for sedation for dental procedures. They were randomly classified into two groups, group I (dexmedetomidine group) was given as 2μg/kg loading dose over 5min followed by 0.4μg/kg/h continuous infusion. Group II (midazolam–propofol group) midazolam was given as 0.05mg/kg and propofol was given loading dose as 1mg/kg over 5min followed by 5mg/kg/h continuous infusion. Heart rate, mean arterial blood pressure, oxygen saturation, respiratory rate were recorded every 5min till discharge. The onset of sedation, procedure time, recovery time, discharge time and the need of analgesia were recorded. The incidence of occurrence of adverse effects was observed. In group I, the mean onset of sedation was significantly longer than in group II, but recovery time was significantly shorter in group I than group II, there are significantly hemodynamics effects in the first 15min and more incidence of occurrence of side effects in group II than group I. There are more analgesic effects of dexmedetomidine in group I than group II postoperatively. Dexmedetomidine is safe and effective when used for sedation in pediatric patients undergoing dental procedures.