Long-term update of the 24954 EORTC phase III trial on larynx preservation

Abstract The long-term results of the EORTC 24954 trial comparing sequential versus alternating chemotherapy and radiotherapy (RT) for patients with locally advanced laryngeal and hypopharyngeal cancer are reported. From 1996 to 2004, 450 patients were randomly assigned (1–1) to a sequential arm (SA...

Full description

Saved in:
Bibliographic Details
Published in:European journal of cancer (1990) 2016-09, Vol.65, p.109-112
Main Authors: Henriques De Figueiredo, B, Fortpied, C, Menis, J, Lefebvre, J.L, Barzan, L, de Raucourt, D, Geoffrois, L, Giurgea, L, Hupperets, P, Leemans, C.R, Licitra, L, Rolland, F, Tesselaar, M, Vermorken, J.B, Grégoire, V
Format: Article
Language:English
Subjects:
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - therapy
Chemoradiotherapy - methods
Cisplatin - administration & dosage
Disease Progression
Dose Fractionation
Female
Fluorouracil - administration & dosage
Hematology, Oncology and Palliative Medicine
Humans
Hypopharyngeal Neoplasms - pathology
Hypopharyngeal Neoplasms - therapy
Laryngeal Neoplasms - pathology
Laryngeal Neoplasms - therapy
Laryngectomy
Larynx
Larynx preservation
Late toxicity
Male
Middle Aged
Organ Sparing Treatments - methods
Radiochemotherapy
Survival Analysis
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract The long-term results of the EORTC 24954 trial comparing sequential versus alternating chemotherapy and radiotherapy (RT) for patients with locally advanced laryngeal and hypopharyngeal cancer are reported. From 1996 to 2004, 450 patients were randomly assigned (1–1) to a sequential arm (SA = induction cisplatin-5fluorouracil followed by a 70Gy-RT for the responders or a total laryngectomy and post-operative RT for the non-responders) and an alternating arm (AA = cisplatin-5fluorouracil alternated with three 2-week courses of 20 Gy-RT for a total dose of 60 Gy). Median follow-up was 10.2 years. Ten-year survival with functional larynx (primary end-point) and overall survival were similar in both arms (18.7% and 33.6% in SA versus 18.3% and 31.6% in AA). Late toxicity was also similar; however, a trend for higher larynx preservation and better laryngeal function was observed in AA.
ISSN:0959-8049
1879-0852
DOI:10.1016/j.ejca.2016.06.024