Predictors of cardiac and lung dose sparing in DIBH for left breast treatment

• Published in: Physica medica 2019-11, Vol.67, p.27-33
• Main Authors: Cao, Ning, Kalet, Alan M., Young, Lori A., Fang, L. Christine, Kim, Janice N., Mayr, Nina A., Meyer, Juergen
• Format: Article
• Language: English
• Subjects: Breast cancer; Breath Holding; Calypso surface transponder; Cardiac and lung dose sparing; DIBH; Female; Heart - radiation effects; Humans; Lung - radiation effects; Organs at Risk - radiation effects; Predictors; Radiometry; Radiotherapy Planning, Computer-Assisted - methods; Unilateral Breast Neoplasms - physiopathology; Unilateral Breast Neoplasms - radiotherapy
• ISSN: 1120-1797; 1724-191X
• DOI: 10.1016/j.ejmp.2019.09.240

•FB-CCDps and FB-HCD correlated equally with DIBH induced mean heart dose reduction.•The ratio of FB-CCDps and FB-HCD was the strongest correlation with heart dose sparing.•A prediction model predicted 1.04 Gy heart dose reduction per unit of FB-CCDps/FB-HCD. This retrospective study of left breast radiation therapy (RT) investigates the correlation between anatomical parameters and dose to heart or/and left lung in deep inspiration breath-hold (DIBH) compared to free-breathing (FB) technique. Anatomical parameters of sixty-seven patients, treated with a step-and-shoot technique to 50 Gy or 50.4 Gy were included. They consisted of the cardiac contact distances in axial (CCDax) and parasagittal (CCDps) planes, and the lateral heart-to-chest distance (HCD). Correlation analysis was performed to identify predictors for heart and lung dose sparing. Paired t-test and linear regression were used for data analysis with significance level of p = 0.05. All dose metrics for heart and lung were significantly reduced with DIBH, however 21% of patients analyzed had less than 1.0 Gy mean heart dose reduction. Both FB-CCDpsdistance and FB-HCD correlated with FB mean heart dose and mean DIBH heart dose reduction. The strongest correlation was observed for the ratio of FB-CCDpsand FB-HCD with heart dose sparing. A FB-CCDps and FB-HCD model was developed to predict DIBH induced mean heart dose reduction, with 1.04 Gy per unit of FB-CCDps/FB-HCD. Variation between predicted and actual mean heart dose reduction ranged from −0.6 Gy to 0.6 Gy. In this study, FB-CCDps and FB-HCD distance served as predictors for heart dose reduction with DIBH equally, with FB-CCDps/FB-HCD as a stronger predictor. These parameters and the prediction model could be further investigated for use as a tool to better select patients who will benefit from DIBH.