Rare case of multi-drug resistant endometrial tuberculosis unveiled by DNA signature studies of the rpoB , katG and inhA genes

Abstract Tuberculosis has been an unrelenting scourge. Early diagnosis of genital tuberculosis is of paramount importance and has for long been a subject of concern. Asymptomatic presentation of the disease and failure of the present tests to accurately diagnose the disease has further exacerbated t...

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Bibliographic Details
Published in:European journal of obstetrics & gynecology and reproductive biology 2012-09, Vol.164 (1), p.114-115
Main Authors: Singhal, Megha, Khanna, Shalini C, Rai, Arvind, Gupta, Sunil, Chauhan, L.S, Prasad, Sudha
Format: Article
Language:English
Subjects:
Antitubercular Agents - therapeutic use
Bacterial Proteins - genetics
Catalase - genetics
DNA, Bacterial - analysis
DNA-Directed RNA Polymerases
Endometrium - microbiology
Female
Humans
Infertility, Female - microbiology
Obstetrics and Gynecology
Oxidoreductases - genetics
Tuberculosis, Female Genital - complications
Tuberculosis, Female Genital - drug therapy
Tuberculosis, Female Genital - microbiology
Tuberculosis, Multidrug-Resistant - drug therapy
Tuberculosis, Multidrug-Resistant - microbiology
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Summary:Abstract Tuberculosis has been an unrelenting scourge. Early diagnosis of genital tuberculosis is of paramount importance and has for long been a subject of concern. Asymptomatic presentation of the disease and failure of the present tests to accurately diagnose the disease has further exacerbated the scenario. We present a case of 29-year-old infertile female previously treated for skin tuberculosis with multidrug-resistant culture negative endometrial tuberculosis that was undiagnosed by the conventional microbiological techniques. PCR detected endometrial tuberculosis infection while sequencing confirmed the drug resistance pattern. We contend that molecular techniques can be used to define treatment in culture-negative tuberculosis. This illustrates the importance molecular techniques in early diagnosis of this asymptomatic insidious disease.
ISSN:0301-2115
1872-7654
DOI:10.1016/j.ejogrb.2012.05.009