Antenatal corticosteroid therapy: Historical and scientific basis to improve preterm birth management

The purpose of this review is to describe the historical and scientific basis of antenatal corticosteroids (ACS) therapy, to improve the management of preterm birth and decreasing rates of respiratory distress syndrome, intraventricular hemorrhage, necrotizing enterocolitis and perinatal mortality i...

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Bibliographic Details
Published in:European journal of obstetrics & gynecology and reproductive biology 2019-03, Vol.234, p.32-37
Main Authors: Briceño-Pérez, Carlos, Reyna-Villasmil, Eduardo, Vigil-De-Gracia, Paulino
Format: Article
Language:English
Subjects:
Adrenal Cortex Hormones - administration & dosage
Adrenal Cortex Hormones - adverse effects
Animals
Antenatal corticosteroids
Betamethasone
Betamethasone - administration & dosage
Betamethasone - adverse effects
Consensus Development Conferences as Topic
Dexamethasone
Dexamethasone - administration & dosage
Dexamethasone - adverse effects
Female
Fetal lung maturation
Fetal Organ Maturity - drug effects
Gestational Age
Humans
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases - prevention & control
Lung - embryology
Pregnancy
Premature Birth - drug therapy
Randomized Controlled Trials as Topic
Therapy
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Summary:The purpose of this review is to describe the historical and scientific basis of antenatal corticosteroids (ACS) therapy, to improve the management of preterm birth and decreasing rates of respiratory distress syndrome, intraventricular hemorrhage, necrotizing enterocolitis and perinatal mortality in premature infants. We searched MEDLINE/PubMed electronic database, the Cochrane Library, using medical subheading search words such as “ACS”, “corticosteroids”, “betamethasone” or “dexamethasone”, matching with “preterm birth”. This practice was initiated by Liggins and Howie in 1972 and is supported by the initial comprehensive meta-analysis of Crowley, Chambers and Keirse, in 1990, the NIH Consensus Development Conference in 1994, the second Consensus Conference to evaluate repeated courses of corticosteroids in 2000 and the practice recommendations of obstetric societies worldwide. ACS therapy before anticipated preterm birth is one of the most important antenatal therapies and an important evidence-based practice for reducing mortality, and decreasing rates of complications in premature infants. Today, there is no controversy that women with preterm birth
ISSN:0301-2115
1872-7654
DOI:10.1016/j.ejogrb.2018.12.025