Spider and wasp neurotoxins: pharmacological and biochemical aspects

Venoms from several arthropods are recognized as useful sources of bioactive substances, such as peptides, acylpolyamines, and alkaloids, which show a wide range of pharmacological effects on synaptic transmission. In this work, we summarize and compile several biochemical and pharmacological aspect...

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Bibliographic Details
Published in:European Journal of Pharmacology 2004-06, Vol.493 (1), p.1-17
Main Authors: Beleboni, Renê de O., Pizzo, Andrea B., Fontana, Andréia C.K., Carolino, Ruither de O.G., Coutinho-Netto, Joaquim, dos Santos, Wagner F.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brazil
Humans
Ion channel
Ion Channel Gating - drug effects
Medical sciences
Neurotoxin
Neurotoxins - chemistry
Neurotoxins - pharmacology
Pharmacology. Drug treatments
Receptor
Sodium Channels - physiology
Spider
Spider Venoms - chemistry
Transporter and Neurotransmitter release
Wasp
Wasp Venoms - chemistry
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Summary:Venoms from several arthropods are recognized as useful sources of bioactive substances, such as peptides, acylpolyamines, and alkaloids, which show a wide range of pharmacological effects on synaptic transmission. In this work, we summarize and compile several biochemical and pharmacological aspects related to spider and wasp neurotoxins. Their inhibitory and stimulatory actions on ion channels, receptors, and transporters involved in mammalian and insect neurotransmission are considered.
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2004.03.049