5-HT7, but not 5-HT2B, receptors mediate hypotension in vagosympathectomized rats

This study evaluated the possible involvement of 5-HT(2B) receptors in long-lasting hypotension to 5-hydroxytryptamine (5-HT), which is predominantly mediated by 5-HT7 receptors, in anaesthetised vagosympathectomized rats. Intravenous injections of 5-HT and 5-carboxamidotryptamine (5-CT) elicited a...

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Bibliographic Details
Published in:European journal of pharmacology 2004-10, Vol.502 (3), p.239-242
Main Authors: CENTURION, David, GLUSA, Erika, SANCHEZ-LOPEZ, Araceli, VALDIVIA, Luis F, SAXENA, Pramod R, VILLALON, Carlos M
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Dose-Response Relationship, Drug
Hypotension - chemically induced
Hypotension - metabolism
Hypotension - physiopathology
Male
Medical sciences
Pharmacology. Drug treatments
Rats
Rats, Wistar
Receptor, Serotonin, 5-HT2B - physiology
Receptors, Serotonin - physiology
Serotonin - analogs & derivatives
Serotonin - pharmacology
Serotonin - toxicity
Serotonin 5-HT2 Receptor Agonists
Serotonin 5-HT2 Receptor Antagonists
Serotonin Antagonists - pharmacology
Vagotomy
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Summary:This study evaluated the possible involvement of 5-HT(2B) receptors in long-lasting hypotension to 5-hydroxytryptamine (5-HT), which is predominantly mediated by 5-HT7 receptors, in anaesthetised vagosympathectomized rats. Intravenous injections of 5-HT and 5-carboxamidotryptamine (5-CT) elicited a dose-dependent hypotension that was dose-dependently antagonised by (R)-1-[(3-hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl) ethyl] pyrrolidine (SB-269970; a selective 5-HT7 receptor antagonist), but not by saline. Interestingly, alpha-methyl-5-(2-thienylmethoxy)-1H-indole-3-ethanamine (BW723C86; a 5-HT(2B) receptor agonist) produced vasopressor responses without affecting hypotension to 5-HT. These results suggest that hypotension to 5-HT and 5-CT is mainly mediated by 5-HT7 receptors, whilst the role of 5-HT(2B) receptors seems unlikely.
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2004.08.050