Peripheral involvement of the nitric oxide–cGMP pathway in the indomethacin-induced antinociception in rat

The role of nitric oxide (NO) in the antinociceptive effect of indomethacin was assessed in the pain-induced functional impairment model in the rat (PIFIR model), a model of inflammatory and chronic pain similar to that observed in clinical gout. Oral administration of indomethacin (5.6 mg/kg), a no...

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Bibliographic Details
Published in:European journal of pharmacology 2004-10, Vol.503 (1), p.43-48
Main Authors: Ventura-Martínez, Rosa, Déciga-Campos, Myrna, Díaz-Reval, Ma. Irene, González-Trujano, Ma. Eva, López-Muñoz, Francisco J.
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Antinociception
Arginine - metabolism
Biological and medical sciences
Chronic Disease
Cyclic GMP - physiology
Disease Models, Animal
Enzyme Inhibitors - pharmacology
Female
Gout - chemically induced
Gout - complications
Gout - psychology
Indomethacin
Indomethacin - pharmacology
Medical sciences
Nerve Tissue Proteins - antagonists & inhibitors
NG-Nitroarginine Methyl Ester - pharmacology
Nitric oxide
Nitric Oxide - physiology
Nitric Oxide Donors - pharmacology
Nitric Oxide Synthase - antagonists & inhibitors
Nitric Oxide Synthase Type I
Nitroprusside - pharmacology
Pain - chemically induced
Pain - drug therapy
Pain Measurement - drug effects
Peripheral Nervous System - drug effects
Pharmacology. Drug treatments
PIFIR model
Rat
Rats
Rats, Wistar
Signal Transduction - physiology
Uric Acid
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Summary:The role of nitric oxide (NO) in the antinociceptive effect of indomethacin was assessed in the pain-induced functional impairment model in the rat (PIFIR model), a model of inflammatory and chronic pain similar to that observed in clinical gout. Oral administration of indomethacin (5.6 mg/kg), a nonselective cyclooxygenase inhibitor, significantly decreased the nociceptive response elicited by uric acid injected into the knee joint of the right hind limb (2.0±3.0 and 149.7±18.0 area units [au], in the absence and the presence of indomethacin, respectively). This effect of indomethacin was reduced in nearly 50% by local pretreatment with the nonselective inhibitor of NO synthase, N G- l-nitro-arginine methyl ester ( l-NAME) (72.9±10.7 vs. 149.7±18.0 au, P
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2004.09.018