Protective effect of astaxanthin on naproxen-induced gastric antral ulceration in rats

Frequently used for humans as non-steroidal anti-inflammatory drug, naproxen has been known to induce ulcerative gastric lesion. The present study investigated the in vivo protective effect of astaxanthin isolated from Xanthophyllomyces dendrorhous against naproxen-induced gastric antral ulceration...

Full description

Saved in:
Bibliographic Details
Published in:European journal of pharmacology 2005-05, Vol.514 (1), p.53-59
Main Authors: Kim, Jeong-Hwan, Kim, Young-Sik, Song, Gwan-Gyu, Park, Jong-Jae, Chang, Hyo-Ihl
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - pharmacology
Animals
Anti-ulcer drug
Astaxanthin
beta Carotene - analogs & derivatives
beta Carotene - pharmacology
Biological and medical sciences
Disease Models, Animal
Dose-Response Relationship, Drug
Gastric antral ulceration
Glutathione Peroxidase - metabolism
Male
Malondialdehyde - metabolism
Medical sciences
Naproxen - administration & dosage
Naproxen - toxicity
Orogastric administration
Pharmacology. Drug treatments
Pyloric Antrum - drug effects
Pyloric Antrum - metabolism
Pyloric Antrum - pathology
Rats
Rats, Sprague-Dawley
Stomach Ulcer - chemically induced
Stomach Ulcer - metabolism
Stomach Ulcer - prevention & control
Superoxide Dismutase - metabolism
Time Factors
Xanthophyllomyces dendrorhous
Xanthophylls
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Frequently used for humans as non-steroidal anti-inflammatory drug, naproxen has been known to induce ulcerative gastric lesion. The present study investigated the in vivo protective effect of astaxanthin isolated from Xanthophyllomyces dendrorhous against naproxen-induced gastric antral ulceration in rats. The oral administration of astaxanthin (1, 5, and 25 mg/kg of body weight) showed a significant protection against naproxen (80 mg/kg of body weight)-induced gastric antral ulcer and inhibited elevation of the lipid peroxide level in gastric mucosa. In addition, pretreatment of astaxanthin resulted in a significant increase in the activities of radical scavenging enzymes such as superoxide dismutase, catalase, and glutathione peroxidase. A histologic examination clearly proved that the acute gastric mucosal lesion induced by naproxen nearly disappeared after the pretreatment of astaxanthin. These results suggest that astaxanthin removes the lipid peroxides and free radicals induced by naproxen, and it may offer potential remedy of gastric ulceration.
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2005.03.034