Chronic β-adrenoceptor stimulation and cardiac hypertrophy with no induction of circulating renin

The hemodynamic and cardiac effects of isoproterenol were examined in rats submitted to chronic salt loading (1% NaCl as drinking water) to prevent activation of the systemic renin–angiotensin system. Isoproterenol treatment for 1 week resulted in 36% and 44% (P

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Bibliographic Details
Published in:European journal of pharmacology 2005-09, Vol.520 (1-3), p.135-141
Main Authors: Oliveira, Edilamar M., Krieger, José E.
Format: Article
Language:English
Subjects:
Adrenergic beta-Agonists - administration & dosage
Adrenergic beta-Agonists - pharmacology
Angiotensin-converting enzyme
Animals
Atrial Natriuretic Factor - genetics
Atrial Natriuretic Factor - metabolism
Cardiac Output - drug effects
Gene Expression Regulation - drug effects
Heart Rate - drug effects
Hypertrophy, Left Ventricular - chemically induced
Hypertrophy, Left Ventricular - physiopathology
Isoproterenol
Isoproterenol - administration & dosage
Isoproterenol - pharmacology
Male
Myocardial hypertrophy
Myocardium - enzymology
Peptidyl-Dipeptidase A - genetics
Peptidyl-Dipeptidase A - metabolism
Rats
Rats, Wistar
Renin - blood
Renin-Angiotensin System - drug effects
Renin-Angiotensin System - physiology
Renin–angiotensin system
RNA, Messenger - metabolism
Sodium Chloride, Dietary
Up-Regulation
β-adrenoceptor
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Description
Summary:The hemodynamic and cardiac effects of isoproterenol were examined in rats submitted to chronic salt loading (1% NaCl as drinking water) to prevent activation of the systemic renin–angiotensin system. Isoproterenol treatment for 1 week resulted in 36% and 44% (P
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2005.07.026