Enhancement of the anti-immobility action of antidepressants by a selective 5-HT7 receptor antagonist in the forced swimming test in mice

Using the forced swimming test in mice, we examined the effect of the following antidepressants: citalopram, imipramine, desipramine and moclobemide (which are characterized by different mechanisms of action), administered in combination with the selective 5-HT7 receptor antagonist (2R)-1-[(3-hydrox...

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Bibliographic Details
Published in:European journal of pharmacology 2007-01, Vol.555 (1), p.43-47
Main Authors: WESOŁOWSKA, Anna, TATARCZYNSKA, Ewa, NIKIFORUK, Agnieszka, CHOJNACKA-WOJCIK, Ewa
Format: Article
Language:English
Subjects:
Adrenergic Uptake Inhibitors - pharmacology
Animals
Antidepressive Agents - pharmacology
Biological and medical sciences
Citalopram - pharmacology
Desipramine - pharmacology
Drug Interactions
Imipramine - pharmacology
Male
Medical sciences
Mice
Moclobemide - pharmacology
Monoamine Oxidase Inhibitors - pharmacology
Motor Activity - drug effects
Pharmacology. Drug treatments
Phenols - pharmacology
Receptors, Serotonin - metabolism
Serotonin Antagonists - pharmacology
Serotonin Uptake Inhibitors - pharmacology
Sulfonamides - pharmacology
Swimming
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Summary:Using the forced swimming test in mice, we examined the effect of the following antidepressants: citalopram, imipramine, desipramine and moclobemide (which are characterized by different mechanisms of action), administered in combination with the selective 5-HT7 receptor antagonist (2R)-1-[(3-hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]-pyrrolidine (SB 269970). All those drugs were given in doses which did not shorten the immobility time of mice. Citalopram (1.25 mg/kg), imipramine (10 mg/kg), desipramine (5 mg/kg) or moclobemide (10 mg/kg) administered jointly with SB 269970 (5 mg/kg), produced a significant antidepressant-like effect. None of the compounds studied, given alone or in combination, increased the spontaneous locomotor activity of mice. The obtained results indicate that blockade of 5-HT7 receptors may facilitate the anti-immobility effect of antidepressants in mice.
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2006.10.001