Ozone oxidative preconditioning inhibits inflammation and apoptosis in a rat model of renal ischemia/reperfusion injury

Ischemia/reperfusion injury, which is commonly seen in the field of renal surgery or transplantation, is a major cause of acute renal failure. Previous studies showed that ozone oxidative preconditioning (OzoneOP) attenuated renal ischemia/reperfusion injury. The objective of this study was to exami...

Full description

Saved in:
Bibliographic Details
Published in:European journal of pharmacology 2008-03, Vol.581 (3), p.306-314
Main Authors: Chen, Hui, Xing, Bianzhi, Liu, Xiuheng, Zhan, Bingyan, Zhou, Jiangqiao, Zhu, Hengcheng, Chen, Zhiyuan
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Apoptosis - drug effects
Biological and medical sciences
Inflammation
Inflammation - physiopathology
Inflammation - prevention & control
Ischemia/reperfusion
Ischemic Preconditioning
Kidney Diseases - physiopathology
Kidney Diseases - prevention & control
Kidney Function Tests
Male
Medical sciences
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Oxidants, Photochemical - pharmacology
Oxidative Stress - drug effects
Ozone - pharmacokinetics
Ozone oxidative preconditioning
Pharmacology. Drug treatments
Rats
Rats, Wistar
Renovascular diseases
Reperfusion Injury - prevention & control
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ischemia/reperfusion injury, which is commonly seen in the field of renal surgery or transplantation, is a major cause of acute renal failure. Previous studies showed that ozone oxidative preconditioning (OzoneOP) attenuated renal ischemia/reperfusion injury. The objective of this study was to examine the role of the OzoneOP in modulating inflammation and apoptosis after renal ischemia/reperfusion injury. Rats were subjected to 45 min of renal ischemia, with or without treatment with OzoneOP (1 mg/kg). Renal function, inflammation and apoptosis were compared at 24 h after renal injury. OzoneOP improved the renal dysfunction and reduced inflammation and apoptosis after ischemia/reperfusion injury. In conclusion, OzoneOP has potent anti-apoptotic and anti-inflammatory properties. These findings may have major implications in the treatment of human ischemic acute renal failure.
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2007.11.050