7-Difluoromethyl-5,4′-dimethoxygenistein inhibits oxidative stress induced adhesion between endothelial cells and monocytes via NF-κB

7-Difluoromethyl-5,4′-dimethoxygenistein (dFMGEN), prepared by the difluoromethylation and alkylation of genistein, is an active new chemical entity. The effects of dFMGEN on cell adhesion and inflammation were investigated in human umbilical vein endothelial cells, and whether its role involved reg...

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Bibliographic Details
Published in:European journal of pharmacology 2009-03, Vol.605 (1), p.31-35
Main Authors: Wang, Li, Zheng, Xing, Xiang, Hong-lin, Fu, Xiao-hua, Cao, Jian-guo
Format: Article
Language:English
Subjects:
7-Difluoromethyl-5,4′-dimethoxygenistein
Adhesion
Endothelial cell
Inflammation
Monocyte
NF-κB
Oxidative stress
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Summary:7-Difluoromethyl-5,4′-dimethoxygenistein (dFMGEN), prepared by the difluoromethylation and alkylation of genistein, is an active new chemical entity. The effects of dFMGEN on cell adhesion and inflammation were investigated in human umbilical vein endothelial cells, and whether its role involved regulation of NF-κB expression was also studied. Results demonstrated that pretreatment with dFMGEN decreased the adhesion between vascular endothelial cells and monocytes, reduced the release of E-Selectin, ICAM-1, IL-6 and TNF-α in vascular endothelial cells, and down-regulated the expression of NF-κB. Therefore, data suggested that dFMGEN can effectually inhibit the adhesion between vascular endothelial cells and monocytes induced by oxidative stress and inflammatory reaction, and its role is connected with the downregulation of NF-κB.
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2009.01.019