Thrombotic thrombocytopenic purpura associated with chronic HCV infection

Thrombotic thrombocytopenic purpura is a potentially lethal microvascular thrombotic disorder. In this study, we report a 32years old woman who suffered from undifferentiated vasculitis with marked improvement on steroids and cyclophosphamide. Two years later, hepatitis C virus infection was discove...

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Bibliographic Details
Published in:Egyptian rheumatologist 2012-07, Vol.34 (3), p.107-110
Main Authors: El Garf, Ayman, Gaber, Wafaa, Elbaz, Tamer, El Garf, Kamal
Format: Article
Language:English
Subjects:
HCV
Interferon
Thrombotic thrombocytopenic purpura
Vasculitis
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Summary:Thrombotic thrombocytopenic purpura is a potentially lethal microvascular thrombotic disorder. In this study, we report a 32years old woman who suffered from undifferentiated vasculitis with marked improvement on steroids and cyclophosphamide. Two years later, hepatitis C virus infection was discovered. Decision for interferon therapy was not recommended at this stage and the patient remained stable for the following 7years. In January 2009, pegylated interferon and ribavirin were started due to worsening of her hepatitis; the treatment was stopped after 12weeks due to the absence of any virologic response. Fourteen months later, she developed severe uncontrolled thrombotic thrombocytopenic purpura that led eventually to her death. We report this rare case of thrombotic thrombocytopenic purpura that may directly be related to chronic HCV infection rather than to interferon therapy.
ISSN:1110-1164
2090-2433
DOI:10.1016/j.ejr.2012.05.001