Vitamin D levels in patients with Behçet’s disease: Significance and impact on disease measures

• Published in: Egyptian rheumatologist 2013-07, Vol.35 (3), p.151-157
• Main Authors: Ganeb, Sahar S, Sabry, Hanan H., El-Assal, Mohammed M., Kamal, Howyda M., Fayed, Ayser A.
• Format: Article
• Language: English
• Subjects: Behçet’s disease; Disease activity; Vitamin D
• ISSN: 1110-1164; 2090-2433
• DOI: 10.1016/j.ejr.2013.01.006

This study aimed to investigate serum levels of vitamin D in patients with Behçet’s disease (BD) and to evaluate their relationship to disease activity as well as different disease measures. Forty-two patients with BD were enrolled into this study. These patients were subjected to detailed history taking, thorough clinical examination including assessment of disease activity according to Behçet’s Disease Current Activity Form (BDCAF) score and performed laboratory investigations including erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), serum calcium, serum phosphorus and serum alkaline phosphatase. Serum 25-hydroxyvitamin D (vitamin D) levels were determined using Enzyme-Linked-Immunosorbent Assay (ELISA). A control group of 41 age and sex matched healthy controls was also included. The mean level of 25-hydroxyvitamin D (30.65±12.87ng/ml) was significantly decreased in BD patients compared to the controls (37.98±15.76ng/ml) (p=0.02). Significant negative correlations of serum vitamin D levels with patients’ ages (p=0.03), ESR (p