A comparative study of vitamin D serum levels in patients with recurrent aphthous stomatitis

• Published in: Egyptian rheumatologist 2015-07, Vol.37 (3), p.133-137
• Main Authors: Khabbazi, Alireza, Ghorbanihaghjo, Amir, Fanood, Farahnoosh, Kolahi, Sousan, Hajialiloo, Mehrzad, Rashtchizadeh, Nadereh
• Format: Article
• Language: English
• Subjects: 25-Hydroxy vitamin D; Oral aphthous ulcer; Recurrent aphthous stomatitis
• ISSN: 1110-1164; 2090-2433
• DOI: 10.1016/j.ejr.2014.07.005

Recurrent aphthous stomatitis (RAS) is characterized by recurrent, painful, shallow, round or oval oral ulcers surrounded by inflammatory halos. To investigate the status of vitamin D in RAS patients and the relationship between vitamin D levels and the severity of RAS. In this cross sectional study 46 patients with idiopathic minor RAS (MIRAS), and 49 age and sex matched healthy controls were included. Patients with at least 3 minor aphthous oral ulcers in a year without any known cause for RAS were determined as idiopathic minor recurrent aphthous stomatitis. The severity of RAS was assessed by the number of oral aphthous ulcers in each attack and the frequency of attacks. 25-Hydroxy vitamin D [25(OH) D] levels were measured by the Enzyme-Linked Immunosorbent Assay (ELISA) method in patients and control groups. The mean 25(OH) D level in the MIRAS group was lower than the control group (12.1±7.7ng/dl vs. 27.4±9.7ng/dl, p=0.0001). Insufficiency and deficiency of 25(OH) D in the recurrent aphthous stomatitis groups were more common than those in the control group (Vitamin D sufficient, Vitamin D insufficient and Vitamin D deficient (p