Krebs von den Lungen-6 (KL-6), soluble programmed cell death-1 (sPD-1) and its ligand-1(sPDL-1) in systemic sclerosis patients: Relation to disease parameters

This study aimed to assess the levels of Krebs von den Lungen-6 (KL-6), soluble programmed cell death-1 (sPD-1) and soluble programmed cell death ligand-1(sPDL-1) in systemic sclerosis (SSc) patients, and to evaluate their relation with disease parameters. Forty-six SSc patients (31 limited, 15 diff...

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Bibliographic Details
Published in:Egyptian rheumatologist 2022-10, Vol.44 (4), p.333-337
Main Authors: El-Shazly, Reem, Niazy, Marwa H., Riad, Nermine M., Abdelraouf, Fatma H., ElRefai, Rasha M.
Format: Article
Language:English
Subjects:
Biomarkers
KL-6
sPD-1
sPD-L1
Systemic sclerosis
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Summary:This study aimed to assess the levels of Krebs von den Lungen-6 (KL-6), soluble programmed cell death-1 (sPD-1) and soluble programmed cell death ligand-1(sPDL-1) in systemic sclerosis (SSc) patients, and to evaluate their relation with disease parameters. Forty-six SSc patients (31 limited, 15 diffuse) and 43 matched controls were included. Serum levels of KL-6, sPD-1, and sPDL-1 were assessed by enzyme-linked immune-sorbent assay (ELISA). Patients mean age was 40.2 ± 12.2 years, disease duration 8.04 ± 6.02 years and females: male was 10.5:1. Levels of KL-6, sPD-1, and sPDL-1 were significantly higher in SSc patients compared to the controls 22.4(14.1–637.6) vs. 14.8(8.9–182.3) (p 
ISSN:1110-1164
2090-2433
DOI:10.1016/j.ejr.2022.05.001