Irisin is associated with atherosclerosis in females with lupus nephritis

Lupus nephritis (LN) is a common presentation for systemic lupus erythematosus (SLE) in rheumatology practice. SLE is associated with increased risk of atherosclerosis. Irisin plays a potential role in preventingatherosclerosis. This study aimed to measure serum irisin level and carotid intima media...

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Bibliographic Details
Published in:Egyptian rheumatologist 2024-04, Vol.46 (2), p.62-66
Main Authors: El Shebiny, Emad M., Shoeib, Sabry A., Shahin, Dina A., Dawood, Ashraf, Mazen, Mohammed R., Zahran, Enas S.
Format: Article
Language:English
Subjects:
Atherosclerosis
CIMT
HDL
Irisin
LDL
Lupus nephritis
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Summary:Lupus nephritis (LN) is a common presentation for systemic lupus erythematosus (SLE) in rheumatology practice. SLE is associated with increased risk of atherosclerosis. Irisin plays a potential role in preventingatherosclerosis. This study aimed to measure serum irisin level and carotid intima media thickness (CIMT) and to unravel the possible risk factors for atherosclerosis in females with LN. This study was carried out on 55 females with LN and 55 matched controls. Laboratory investigations included urinary protein/creatinine ratio, anti-double stranded deoxyribonucleic acid (anti-ds-DNA) titre and lipid profile and carotid intima media thickness (CIMT) estimated by duplex ultrasound. The SLE disease activity index (SLEDAI) was assessed. Serum irisin level was measured by enzyme linked immunosorbent assay. CIMT was 0.8 ± 0.12 mm in cases, and serum irisin mean was 10.3 ± 3.1 ng/ml. Serum irisin significantly correlated with high density lipoprotein (HDL) (r = 0.3,p 
ISSN:1110-1164
2090-2433
DOI:10.1016/j.ejr.2024.01.001