MRI of fetal acquired brain lesions

Acquired fetal brain damage is suspected in cases of destruction of previously normally formed tissue, the primary cause of which is hypoxia. Fetal brain damage may occur as a consequence of acute or chronic maternal diseases, with acute diseases causing impairment of oxygen delivery to the fetal br...

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Bibliographic Details
Published in:European journal of radiology 2006-02, Vol.57 (2), p.233-249
Main Authors: Prayer, Daniela, Brugger, Peter C., Kasprian, Gregor, Witzani, Linde, Helmer, Hanns, Dietrich, Wolfgang, Eppel, Wolfgang, Langer, Martin
Format: Article
Language:English
Subjects:
Acquired fetal brain injury
Brain Injuries - diagnosis
Diffusion-weighted sequences
Female
Fetal Diseases - diagnosis
Fetal magnetic resonance imaging
Fetus - abnormalities
Humans
Magnetic Resonance Imaging - methods
Pregnancy
Prenatal Diagnosis
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Summary:Acquired fetal brain damage is suspected in cases of destruction of previously normally formed tissue, the primary cause of which is hypoxia. Fetal brain damage may occur as a consequence of acute or chronic maternal diseases, with acute diseases causing impairment of oxygen delivery to the fetal brain, and chronic diseases interfering with normal, placental development. Infections, metabolic diseases, feto-fetal transfusion syndrome, toxic agents, mechanical traumatic events, iatrogenic accidents, and space-occupying lesions may also qualify as pathologic conditions that initiate intrauterine brain damage. MR manifestations of acute fetal brain injury (such as hemorrhage or acute ischemic lesions) can easily be recognized, as they are hardly different from postnatal lesions. The availability of diffusion-weighted sequences enhances the sensitivity in recognizing acute ischemic lesions. Recent hemorrhages are usually readily depicted on T2 (*) sequences, where they display hypointense signals. Chronic fetal brain injury may be characterized by nonspecific changes that must be attributable to the presence of an acquired cerebral pathology. The workup in suspected acquired fetal brain injury also includes the assessment of extra-CNS organs that may be affected by an underlying pathology. Finally, the placenta, as the organ that mediates oxygen delivery from the maternal circulation to the fetus, must be examined on MR images.
ISSN:0720-048X
1872-7727
DOI:10.1016/j.ejrad.2005.11.023