Noninvasive assessment of liver fibrosis by dual-layer spectral detector CT

•The iodine-density ratio (I-ratio) and the CT-extracellular volume (ECV) increased as the fibrosis stage advanced.•The CT-ECV has a higher diagnostic performance than the I-ratio.•The CT-ECV can be useful for predicting a high stage of liver fibrosis. To elucidate the diagnostic ability of liver fi...

Full description

Saved in:
Bibliographic Details
Published in:European journal of radiology 2021-03, Vol.136, p.109575, Article 109575
Main Authors: Morita, Koichiro, Nishie, Akihiro, Ushijima, Yasuhiro, Takayama, Yukihisa, Fujita, Nobuhiro, Kubo, Yuichiro, Ishimatsu, Keisuke, Yoshizumi, Tomoharu, Maehara, Junki, Ishigami, Kousei
Format: Article
Language:English
Subjects:
Dual layer spectral detector CT
Extracellular volume
Female
Fibrosis
Humans
Iodine
Iodine density
Liver - diagnostic imaging
Liver - pathology
Liver Cirrhosis - diagnostic imaging
Liver Cirrhosis - pathology
Liver fibrosis
Male
Middle Aged
Tomography, X-Ray Computed
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•The iodine-density ratio (I-ratio) and the CT-extracellular volume (ECV) increased as the fibrosis stage advanced.•The CT-ECV has a higher diagnostic performance than the I-ratio.•The CT-ECV can be useful for predicting a high stage of liver fibrosis. To elucidate the diagnostic ability of liver fibrosis using (1) liver parenchymal iodine density on equilibrium computed tomographic imaging and (2) extracellular volume (ECV) measured by dual-layer spectral detector CT. From April 2018 to June 2019, 68 patients [mean age, 62 years; 39 males, 29 females] underwent dynamic contrast-enhanced CT by a dual-layer spectral detector CT system before liver transplantation or liver resection. The iodine densities of liver parenchyma (I liver) and aorta (I aorta) were independently measured by two radiologists at the equilibrium phase. The iodine-density ratio (I-ratio) (I liver/ I aorta) and the CT-ECV were calculated. Spearman's rank correlation coefficient was used to analyze the relationship between the I-ratio or the CT-ECV and the fibrosis stage. A receiver operating characteristic (ROC) curve analysis was performed to determine the accuracy of the I-ratio and the CT-ECV for discriminating fibrosis stages. For both readers, the I-ratio and the CT-ECV increased significantly as the fibrosis stage advanced (I-ratio: rho = 0.380 and 0.443, p 
ISSN:0720-048X
1872-7727
DOI:10.1016/j.ejrad.2021.109575