Free water and iron content in the substantia nigra at different stages of Parkinson's disease

Abnormalities in free water (FW) and susceptibility values exist in the substantia nigra (SN) of patients with Parkinson's disease (PD), but their role in characterizing the disease processes remains uncertain. This study investigated these values at various SN locations and stages of PD, and t...

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Bibliographic Details
Published in:European journal of radiology 2023-10, Vol.167, p.111030, Article 111030
Main Authors: Chen, Mingxing, Wang, Yutong, Zhang, Chunyan, Li, Jun, Li, Zhenghao, Guan, Xiaojun, Bao, Jianfeng, Zhang, Yuyao, Cheng, Jingliang, Wei, Hongjiang
Format: Article
Language:English
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Summary:Abnormalities in free water (FW) and susceptibility values exist in the substantia nigra (SN) of patients with Parkinson's disease (PD), but their role in characterizing the disease processes remains uncertain. This study investigated these values at various SN locations and stages of PD, and their relationship with clinical symptoms. FW and quantitative susceptibility mapping (QSM) values were evaluated in the anterior and posterior SN, along with swallow-tail-sign (STS) ratings, in patients with PD (early-stage: n = 39; middle-to-advanced-stage: n = 97) and healthy controls (n = 82). The correlation between these indices and motor and non-motor symptoms, and their capability to distinguish PD from healthy controls, were also examined. Increased FW in the anterior and posterior SN and increased QSM values in the posterior SN were observed in both early-stage and middle-to-advanced-stage PD patients (p 
ISSN:0720-048X
1872-7727
DOI:10.1016/j.ejrad.2023.111030