Erroneous diagnosis of pancreatic cancer after radiotherapy of testicular cancer

Background: After radiotherapy with or without chemotherapy radiation-induced normal tissue alteration may mimic cancer and may cause major morbidity. Results: Two patients irradiated for seminoma, in one case combined with cisplatin-based chemotherapy, developed clinical symptoms and radiological s...

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Bibliographic Details
Published in:European journal of surgical oncology 2004-04, Vol.30 (3), p.352-355
Main Authors: Stensvold, E, Aass, N, Gladhaug, I, Stenwig, A.E, Claussen, O.P, Fosså, S.D
Format: Article
Language:English
Subjects:
Biliary Tract Surgical Procedures - methods
Diagnostic Errors
Fibrosis
Humans
irradiation
Male
Middle Aged
pancreas cancer
Pancreatic Diseases - diagnosis
Pancreatic Diseases - etiology
Pancreatic Diseases - pathology
Pancreatic Diseases - surgery
Pancreatic Neoplasms - diagnosis
Radiation Injuries - complications
Radiation Injuries - diagnosis
Radiation Injuries - pathology
Radiation Injuries - surgery
Radiotherapy - adverse effects
Seminoma - radiotherapy
testicular cancer
Testicular Neoplasms - radiotherapy
Treatment Outcome
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Summary:Background: After radiotherapy with or without chemotherapy radiation-induced normal tissue alteration may mimic cancer and may cause major morbidity. Results: Two patients irradiated for seminoma, in one case combined with cisplatin-based chemotherapy, developed clinical symptoms and radiological signs comparable to pancreatic cancer (stenosis of the ductus choledochus). The non-malignant diagnosis was finally established by revision of the histological specimen (case 1) and per-operatively (case 2). In both patients by-pass operations for biliary tract stenosis resulted in excellent palliation. Conclusion: Radiation-induced fibrosis within the upper retroperitoneal space is an important differential diagnosis versus pancreatic cancer in patients with prior radiotherapy for seminoma. Diagnosis based only on clinical and radiological findings may lead to incorrect patient information and registration errors in Cancer Registries.
ISSN:0748-7983
1532-2157
DOI:10.1016/j.ejso.2003.09.006