The role of 18F-FDG PET/CT in detecting synchronous regional and distant metastatic disease in patients with an in-breast tumour recurrence

• Published in: European journal of surgical oncology 2024-12, p.109564, Article 109564
• Main Authors: Walstra, Coco J.E.F., Schipper, Robert-Jan, Voogd, Adri C., van der Sangen, Maurice J.C., van Duin, Ruben T.N.W., van Riet, Yvonne E., Smidt, Marjolein L., Bloemen, Johanne G., Wyndaele, Dirk N.J., Nieuwenhuijzen, Grard A.P., Zeillemaker, A.M., Luiten, E.J.T., van der Velden, S., Doeksen, A., Frakking, T.T., Jeuriens, S., Brokx, H.A.P., de Widt, L., Jansen, P., Lemaire, B.M.D., Koppert, L.B., Klem, T.M.A.L., Truin, W., van Beurden, A., Merkus, J., Vles, W.J., Liefers, G.J., Maaskant-Braat, A.J., Straver, M., Dassen, A.E., Gooiker, G.A., Schlooz-Vries, M.S., Rutter, J.E., Brink, A.C., Smit, L.H., Aarts, F., Brookman, S., Muller, S., de Roos, W., Evers, D.J., van Dessel, E., van Bastelaar, J., Outmani, L., Postma, E.L., Bargon, C.A., Besten, S. den, Peters, H., Daniels, L., Verheuvel, N., Zeestraten, E.C.M., Raben, A.M.T.J., van de Wetering, J.C., Hagenaars, S.C., van Roosendaal. L. Cornelissen, L.M., Stokmans, S., van Bergen, E., Broek, R.P.G. ten, van Uden, D.J.P., Schreurs, S., Hardon, S.F., Dulfer, R.R., de Rooij, L.
• Format: Article
• Language: English
• ISSN: 0748-7983
• DOI: 10.1016/j.ejso.2024.109564

In line with the trend towards minimally invasive, patient-tailored treatment, a selected group of patients with an in-breast tumour recurrence (IBTR) is treated by repeat breast-conserving treatment (BCT). To select eligible patients for repeat BCT, a reliable pre-operative work-up is essential. This study reports on the role of 18F-FDG PET/CT in detecting synchronous regional and distant metastases in patients with IBTR. A nation-wide data query was sent out to all Dutch hospitals offering breast cancer treatment. Breast cancer surgeons from 34 hospitals participated, filling electronic case report forms (eCRFs) on 549 patients treated for IBTR from 2016-2017. Of the 549 included patients, 297 were screened using 18F-FDG PET/CT for the presence of distant metastases. Forty of them (13.5%) presented with synchronous distant metastatic disease. In 168 clinically node-negative patients who underwent 18F-FDG PET/CT, a suspect regional lymph node was found in 18 (10.7%). Final pathology of these lymph nodes yielded a positive lymph node in 12 patients (7.1%). Positive predictive value (PPV) of 18F-FDG PET/CT in clinically node-negative patients was 66.7% and negative predictive value (NPV) was 85.3%. The clinically relevant percentage of synchronous distant metastatic disease justifies the use of 18F-FDG PET/CT in the workup of patients with an IBTR. Furthermore, 18F-FDG PET/CT can assist in detecting regional axillary lymph node metastases, but requires histopathological confirmation given the moderate PPV, before clinical decisions can be made.