Cold Agglutinin Related Acrocyanosis and Paroxysmal Haemolysis

The clinical features of severe cold agglutinin related paroxysmal agglutination and haemolysis could be confused with a number of conditions. A 61-year old lady presented with features of acute peripheral ischaemia who had recently been started on treatment for Raynaud's disease. Haematologica...

Full description

Saved in:
Bibliographic Details
Published in:European journal of vascular and endovascular surgery 2005-11, Vol.30 (5), p.563-565
Main Authors: Sinha, A., Richardson, G., Patel, R.T.
Format: Article
Language:English
Subjects:
Acrocyanosis
Anemia, Hemolytic, Autoimmune - diagnosis
Anemia, Hemolytic, Autoimmune - therapy
Antineoplastic Agents, Alkylating - therapeutic use
Chlorambucil - therapeutic use
Cold agglutinins
Cyanosis - etiology
Cyanosis - therapy
Diagnosis, Differential
Female
Glucocorticoids - therapeutic use
Hemoglobinuria, Paroxysmal - diagnosis
Hemoglobinuria, Paroxysmal - therapy
Hot Temperature - therapeutic use
Humans
Immunoglobulin kappa-Chains - blood
Immunoglobulin M - blood
Middle Aged
Paraproteins - analysis
Paroxysmal haemolysis
Prednisolone - therapeutic use
Raynaud Disease - diagnosis
Raynaud's disease
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The clinical features of severe cold agglutinin related paroxysmal agglutination and haemolysis could be confused with a number of conditions. A 61-year old lady presented with features of acute peripheral ischaemia who had recently been started on treatment for Raynaud's disease. Haematological investigations revealed the presence of potent cold haemagglutinins to be the cause of her symptoms but no definite cause for the raised titres were found. She was managed conservatively by keeping her hands and feet warm and regular chlorambucil for a suspected underlying lymphoproliferative disorder. It is important to differentiate the features of Raynaud's disease from those of severe haemagglutination so that identification of any underlying disorder can be made and appropriate treatment instituted.
ISSN:1078-5884
1532-2165
DOI:10.1016/j.ejvs.2005.05.031